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Epub 01/19/2021

Dimers of mitochondrial ATP synthase form the permeability transition pore

Recent studies have shown that upregulation of FAO occurs predominantly in conditions of nutrient deprivation, with dual inhibition of FAO (using etomoxir) and glucose metabolism (using 2-deoxy-D-glucose [2-DG]) yielding significant benefits in animal models of glioma [123]

Therefore, iron metabolism-targeted interventions not only modulate systemic iron homeostasis but also directly maintain mitochondrial integrity, providing a mechanistic basis for their therapeutic potential in IDD